211 
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As of January 2, 2012: $6,827,000.00
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Prima Biomed - 30 Day Poll
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Latest Company News
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Prima BioMed Limited Announces Grant Of Japanese Patent For Cripto-1 Antibody
Reuters Key Development - Jan 17, 2012 |
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Prima BioMed Limited Exercises Options Into New Ordinary Shares
Reuters Key Development - Dec 9, 2011 |
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Prima BioMed Limited Exercises Options Into New Ordinary Shares
Reuters Key Development - Dec 2, 2011 |
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Prima BioMed Limited Exercises Options Into New Ordinary Shares
Reuters Key Development - Nov 22, 2011 |
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Prima BioMed Limited Exercises Options Into New Ordinary Shares
Reuters Key Development - Nov 15, 2011 |
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Prima BioMed Limited Exercises Options Into New Ordinary Shares
Reuters Key Development - Nov 2, 2011 |
Website
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Company Profile
The company has 3 programs in place.
The lead program, CVacTM has completed Phase IIa clinical trials and focuses on the development of an ex vivo immunotherapy for ovarian cancer. The CVac product consists of an adjuvant, attached to a tumour cell surface protein. The treatment is patient-specific and delivered to patients via dendritic cell therapy i.e.patient’s dendritic cells are isolated from their blood & surface protein is mixed with the cells to introduce the protein so it is expressed on the surface of the cells. Cells are then re-introduced to the patient. A successful phase I trial was completed which examined the safety of the product in patients with adenocarcinomas. All patients produced an immune response to the product. The phase IIa clinical trial to determine clinical activity in ovarian cancer announced evidence of clinical activity in response to CVacTM therapy. CVacTM demonstrated a positive clinical response or stabilisation of disease in four of the twenty-one patients.
The second program is focussing on the identification of an antibody to tumour cell target, cripto-1. This program has been partnered with Medarex Inc. (see our USA sister website).
The third is focussing on the development of an adjuvant in Cancer & infectious disease vaccines. It could be coupled to a variety of antigens from viruses, bacteria or parasites to induce a protective immune responses (antibody and T cells). Biological proof of principal has been achieved and early product development has commenced.
Finances
The lead program, CVacTM has completed Phase IIa clinical trials and focuses on the development of an ex vivo immunotherapy for ovarian cancer. The CVac product consists of an adjuvant, attached to a tumour cell surface protein. The treatment is patient-specific and delivered to patients via dendritic cell therapy i.e.patient’s dendritic cells are isolated from their blood & surface protein is mixed with the cells to introduce the protein so it is expressed on the surface of the cells. Cells are then re-introduced to the patient. A successful phase I trial was completed which examined the safety of the product in patients with adenocarcinomas. All patients produced an immune response to the product. The phase IIa clinical trial to determine clinical activity in ovarian cancer announced evidence of clinical activity in response to CVacTM therapy. CVacTM demonstrated a positive clinical response or stabilisation of disease in four of the twenty-one patients.
The second program is focussing on the identification of an antibody to tumour cell target, cripto-1. This program has been partnered with Medarex Inc. (see our USA sister website).
The third is focussing on the development of an adjuvant in Cancer & infectious disease vaccines. It could be coupled to a variety of antigens from viruses, bacteria or parasites to induce a protective immune responses (antibody and T cells). Biological proof of principal has been achieved and early product development has commenced.
Finances
Prima Biomed reported negative cash flow of $4.82m for quarter ended 30 September 2011. Operating cash flow for the period was $(5.26m). Investing cash flow was $(129,000). Financing cash flow was $569,000. Cash in hand at the end of the quarter was $51.11m.
Of Note:
Dendreon is a similar company in terms of technological apporach and has done well so far re prostate cancer - see our sister USA website
Dendreon is a similar company in terms of technological apporach and has done well so far re prostate cancer - see our sister USA website
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